PHD1

Prolyl Hydroxylase Domain 1, EGLN2

PHD1 is a HIF prolyl hydroxylase that regulates HIF-1 protein levels in mammalian cells. HIF-1α prolyl hydroxylases mainly include PHD1, PHD2, and PHD3. These three enzymes have sequence-similar catalytic domains and conserve amino acid residues for coordinating Fe(II) ions. Under hypoxic conditions, due to insufficient oxygen supply, the hydroxylase activity of PHD1 decreases, leading to HIF-1α accumulation and inducing the expression of HRE-regulated target genes. Therefore, PHDs are considered intracellular oxygen sensors. PHD1 is found only in the cell nucleus, while PHD2 is mainly located in the cytoplasm.

References:

[1]. Yasumoto K, et al. Role of the intracellular localization of HIF-prolyl hydroxylases. Biochim Biophys Acta. 2009 May;1793(5):792-7. [Content Brief]

PHD1 Degrader (1)

PHD1 Related Products (1):

Cat. No.	Product Name	Effect	Purity

HY-183995

SH-26	Degrader
SH-26 is a PHD1 PROTAC degrader with DC₅₀s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively. SH-26 recruits CRBN to induce PHD1 degradation via the ubiquitin-proteasome system. SH-26 attenuates APAP (HY-66005)-triggered ROS accumulation, mitochondrial dysfunction, and NLRP3 inflammasome activation. SH-26 can be used for the research of acute liver injury.

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